On the contrary, p53 was upregulated after the administration of radiation doses of 6 and 8 Gy; however, no significant changes were observed between these two doses (Figure S3, panels B, D), indicating that IR treatment at a dose of 6 Gy is sufficient to induce a stabilization of p53 in ACC cell lines. This evidence concerns the gene TP53 and adrenal cortex carcinoma.