In this study, we used cultured human primary renal cancer cells and RCC cell lines including 786-0 (VHL-mutant) and Caki-1(VHL-normal) to study the role of Epo/EpoR pathway on cell proliferation, apoptosis, invasiveness, and sensitivity to anti-tumor drug Sunitinib in RCC cells. The gene discussed is VHL; the disease is renal cell carcinoma.