SMARCA4 and melanoma: [27], [39] BRG1, the catalytic subunit of the SWI/SNF chromatin remodelling complex, is a novel binding partner of the tumor suppressor p16INK4a, which is one of the most important melanoma susceptibility genes identified to date [40] and is involved in melanoma initiation [20]. Bim is a novel member of the Bcl-2 family that promotes apoptosis [41].