Interestingly, PI3K as well as NF-κB and Bcl2 were reported to be a molecular target of plumbagin in human breast cancer cells–plumbagin dramatically decreased the level of the PI3K subunit p85, thereby inhibiting the downstream Akt/mTor pathway leading to growth arrest and cell death [14], [15]. This evidence concerns the gene NFKB1 and breast cancer.