CD8A and HIV infectious disease: Therefore, the viral suppression during early phase of HIV infection is depended on the balance between the gain of polyfunctional HIV-specific CD8+T cells which could enhance the capacity to contain the viral replication and the loss of cytotoxic activities and proliferative capacity which attenuate the ability to eliminate HIV-infected target cells, and with the elapse of infection time this balance will progressively incline to the loss of functions [25], [26].