Although it is known that the epitope-specific CD8+ T cells developed multiple functionalities during primary HIV infection and gradually lose their functionalities with the progression into chronic stages, however, with the addition of the newly developed epitope-specific CD8+ T cells with multiple functionalities during chronic infection, the overall pictures of total CD8+ T cell responses will be different from the epitope-specific CD8+ T cell responses [16], and may more relevant to viral control during HIV-1 chronic infection. The gene discussed is CD8A; the disease is HIV infectious disease.