LXN and neoplasm: Figure 2B depicts the quantitative variation in methylation for each CpG site among nine tumor cell lines. Almost complete methylation was seen in J45.01, U937, Jurkat, Molt4 and CCRF-CEM (>90%) lines, which commensurately showed an absence of Lxn expression. Scatteredly methylated CpG sites were found in K562, KG-1 and SupB15 lines, which were linked to the weak expression of Lxn. Surprisingly, although HL-60 had very low Lxn expression, we found that none of the CpG sites were methylated.