RARRES1 and neoplasm: [21] Both often occur through aberrant DNA methylation that is accentuated during aging. [22], [23], [24], [25], [26], [27] A CpG-enriched region was identified in Lxn promoter and its hypermethylation was found in a variety of human gastric carcinoma cell lines. [18] Promoter hypermethylation of TIG1 was also associated with its silencing in tumor cells. [13], [16] However, it is not known whether Lxn expression is regulated by promoter methylation in hematopoietic malignancy.