To further study the tumor suppressor activity of CDO1 in CRC cell lines, we established clones stably expressing CDO1 and then selected clones with relatively high levels of CDO1 in HCT116 (pCDO1-#5 and pCDO1-Pool) and DLD-1 cells (pCDO1-#2) (Fig. S3C). Here, CDO1 is linked to neoplasm.