In our earlier studies, we examined newly identified cancer-specific methylated genes in a panel of 300 primary tumors representing 13 types of cancer; oncostatin M receptor-β (OSMR) and β-1,4-galactosyltransferase-1 (B4GALT1) were two of the new genes identified in the study to be methylated in primary CRC tissues but rarely in corresponding normal adjacent mucosa and in non-malignant normal colon tissues [23]. This evidence concerns the gene OSMR and cancer.