HSPA5 and neoplasm: PAT-SM6 also binds low density lipoprotein (LDL) and oxidized LDL [8] leading to a working model for the tumour-specific apoptotic activity of PAT-SM6 whereby PAT-SM6 delivers excess lipid in the form of bound LDL or oxidized LDL into tumours by binding to modified GRP78 present on the surface of tumour cells [8].