In the four different pancreatic cancer cell lines, after 24 h treatment, KCN1 significantly induced cell cycle arrest in the G1 phase in a dose-dependent manner, with initial effects beginning at 5 μM in HPAC (P<0.01), BxPC3 (P<0.01), and Mia Paca-2 (P<0.01) cells, and 12.5 μM in Panc-1 (P<0.01) cells (Table 1). The gene discussed is KCNA10; the disease is familial pancreatic carcinoma.