The key significance of the finding of a significant negative correlation between mRSS and sL-selectin concentration in the plasma of dSSc patients is the suggestion that in vivo modulation of L-selectin, or its ligands, is a pathway for reducing collagen deposition, fibrosis, and avascularization in the skin (the body’s largest organ) in the most desperate of patients with systemic sclerosis, that is, those patients with the diffuse form of the disease. Here, SELL is linked to systemic sclerosis.