It has been reported in a study done in Japan that while the frequency of expression on L-selectin on CD8+ T cells was insignificantly different (p>0.0500) in the peripheral blood of 14 SSc cases compared with to 18 health controls, the frequency of expression of L-selectin on the CD161+CD8+ subset of T cells was significantly increased (p<0.0100) in SSc cases compared to health controls [33]. This evidence concerns the gene KLRB1 and systemic sclerosis.