We generated MUC1-transfected mouse colon carcinoma SL4 cells (SL4-MUC1 cells), which are highly tumorigenic and metastatic in C57BL/6 (B6) mice, and control cells transfected with the empty vector (SL4-mock cells) that exhibited similar growth behavior to the SL4-MUC1 cells. This evidence concerns the gene MUC1 and colon carcinoma.