They have shown that the insulin Akita (Ins2Akita) mice crossed with null B2R (In2Akita/B2R−/−) or with double-null B2R and B1R (In2Akita/B2R−/−/B1R−/−) displayed increased albuminuria compared to Ins2Akita mice alone [32], [33].Other factors contributing to these apparent differences in the role of B2R in DN may be attributed to differences in the model of DN studied, genetic background of the animal models studied, severity and metabolic control of the diabetic state, specifics of the experimental design, the end points measured. Here, BDKRB2 is linked to liver dysplastic nodule.