BDKRB2 and diabetic kidney disease: In this study, we employed a global microarray analysis coupled with systems biology study to investigate the differential gene expression in wild type control (B2R+/+) and diabetic (B2R+/+D) mice as well as in B2R knockout-control (B2R−/−) mice and in B2R knockout-diabetic (B2R−/−D) mice in order to identify candidate genes that may be involved in the development of diabetic nephropathy.