ACHE and Cirrhosis: Interestingly, in the rat model of cirrhosis, despite the overall decrease in AChE activity due to tetramer depletion, we have also observed an increase in some immunoreactive AChE band, which can be attributed in part to inactive AChE, as well as to an increase of the R transcript [13], demonstrating again, similarities between the cirrhotic rat model and the disease in humans.