INS and obesity due to melanocortin 4 receptor deficiency: Table 1 lists the top tissue-specific pathways that are significantly correlated with the plasma insulin level. Many studies have suggested the relevance of these pathways to obesity and diabetes, such as Biosynthesis of unsaturated fatty acids, Fatty acid biosynthesis, Butanoate metabolism, and Oxidative phosphorylation [4]. The complete list of trait relevant pathways is available in Table S1.