These include IFI44L, IFIT1, G1P2, IFIT4, RSAD2, MX1, MT1X, STAT1, OAS, IRF7, IFI35 and BST2. HIST1H2BG appeared to have similar expression in all IgSC and is differentially upregulated in tonsil PC compared to tonsil non Ig secreting B cells (Figure 1 and Table S1) and SLE PC compared to the remaining SLE B cells (Figure 2 and Table S2). Here, ISG15 is linked to systemic lupus erythematosus.