The genes DDX60, CACNA1A, KIAA0141 and HLADQB1 are differentially upregulated in the SLE naive and memory compartments compared to normal naive and memory B cells and are differentially downregulated in SLE PC compared to SLE naïve and memory B cells (Figure 2). The gene discussed is HLA-DQB1; the disease is systemic lupus erythematosus.