CSF3 and Decreased total neutrophil count: Hematologic toxicity consisted of four episodes of Grade 4 neutropenia (one patient received granulocyte colony-stimulating factor, another was admitted for rehydration and antibiotics), four episodes of Grade 3 neutropenia, one Grade 3 anemia (one patient received a red blood cell transfusion) and one Grade 3 thrombocytopenia.