IGHE and Alzheimer disease: However, 7/16 of the markers of brain amyloid burden – c-peptide, von Willebrand factor, serum amyloid p-component, AXL receptor tyrosine kinase, interleukin-13, matrix metalloproteinase-9 total and IgE – were not found to associate with any of the surrogate phenotypes of AD pathology that were tested.