The locus with the strongest evidence of interaction with allergic status did not reach genome-wide significance either [estimated pooled odds ratio for interaction between rs17136561 (located in SLC22A23 which overlaps with PSMG4 and TUBB2B) and hay fever status  = 1.64; 95% confidence interval 1.33 to 2.02, P = 2.3×10−6; Figure S3]. This evidence concerns the gene PSMG4 and seasonal allergic rhinitis.