Consistent with our Stage2 results, we saw directionally consistent evidence of association at rs13408661 (P = 7.0×10–6) in the IL1RL1/IL18R1locus and rs9268516 in the HLA region (P = 0.069); rs7861480 near IFNE showed directional consistency but was not significantly associated with asthma in GABRIEL (P = 0.19). The gene discussed is IL1RL1; the disease is asthma.