The link between the activation of TLR2 and 4 and intestinal disease have been reportedpreviously, both in the colon and the ileum of patients with inflammatory bowel diseases.TLR4 was strongly up-regulated in the intestinal epithelium of patients with both ulcerativecolitis and Crohn's disease [18] inadults and children [19]. The gene discussed is TLR4; the disease is intestinal disorder.