Expression of PPARβ/δ mRNA and protein is lower in human and Apc (+/Min-FCCC) mouse colon tumors in respect of matched normal tissue, and stable overexpression of PPARβ/δ in human HT29 colon cancer cell lines enhances ligand activation of PPARβ/δ and inhibition of clonogenicity [33]. The gene discussed is PPARD; the disease is colonic neoplasm.