PPARγ agonists such as thiazolidinediones, also known as glitazones (rosiglitazone, troglitazone, and pioglitazone), have been shown to induce apoptosis in human colon cancer cells, and the molecular mechanism involves glycogen synthase kinase-3β (GSK-3β), a crucial activator of nuclear factor-kappa B (NF-kappaB), which plays a critical role in the mediation of survival signals in cancer cells, with inhibition of NF-kappaB activity and GSK-3β expression in a dose-dependent manner. The gene discussed is GSK3B; the disease is cancer.