PPARG and neoplasm: A series of evidence suggests that PPARG is a tumor suppressor gene in colorectal cancer: (i) loss of function point mutations has been evidenced in one allele of PPARG in primary colorectal patients, and the mutations impair the function of PPARγ by affecting the ligand-binding domain, which results in an inability to bind ligands and control gene regulation; (ii) polymorphism in the PPARγ gene has been found in colorectal cancer patients; (iii) expression of PPARγ in colorectal cancer is associated with a good prognosis [24].