Moreover thiazolidinediones (TZD, class of PPARγ ligands) have been suggested as useful drugs for HCC chemoprevention and treatment as TZD administration in hepatitis B virus (HBV)-transgenic mice reduced tumor incidence in the liver, inhibiting hepatocyte proliferation and increasing apoptosis, probably through inhibition of nucleophosmin (NPM) protein and mRNA expression [68]. This evidence concerns the gene PPARG and hepatocellular carcinoma.