PPARG and esophageal adenocarcinoma: In the esophagus, the evaluation of PPARγ protein and mRNA expression levels in samples of normal esophageal squamous epithelium, Barrett's esophagus, and esophageal adenocarcinoma has shown a trend toward increased expression going from normal tissue to pathological samples and a trend towards increased PPARγ expression with decreasing levels of differentiation [20].