PPARγ inhibits tumor growth only in the presence of functional APC but not in cells with loss of APC function [19], and PPARγ agonists have been reported to have tumor-promoting effects in the ApcMin⁡/+ mice [10], suggesting that loss of APC may alter the normal response of intestinal epithelial tumor cells to PPARγ agonists. Here, APC is linked to neoplasm.