A recent meta-analysis has found an association between the PPARG polymorphism 34 C > G and colon cancer risk [15], and a PPARG germline mutation replacing serine 289 with cysteine in the mature protein (S289C) has been reported associated with dyslipidemia and colonic polyp formation progressing to full-blown adenocarcinoma [16]. This evidence concerns the gene PPARG and adenocarcinoma.