This is further supported by evidence that previous GWAS for RA have also identified genes related to the NF-κB pathway, such as TNFAIP3[13], v-rel reticuloendotheliosis viral oncogene homolog (REL [MIM 164910]) [5], TNF receptor-associated factor 1 (TRAF1 [MIM 601711]) [3], and CD40 molecule TNF receptor superfamily member 5 (CD40 [MIM 109535]) [38]. Here, CD40 is linked to rheumatoid arthritis.