TNF and myeloid sarcoma: HP1 proteins are particularly interesting in the context of MS because in addition to their possible function in the silencing of repeated DNA [27], [28], they are present on the promoters of a number of genes involved in immune defense, including the immunomodulatory cytokine TNFα[29], the interleukins IL1β[30], [31], IL6[32], and IL8[33], and several interferon-inducible genes [34].