The fact that PADI4 is a regulator of cytokines that can be either positively regulated by cellular stimuli or negatively regulated by specific inhibitors provides yet unexplored avenues to the control of inflammation, and in the case of MS, molecules such as Cl-amidine may potentially allow restoring chromatin-mediated repression of over-activated cytokine genes. Here, PADI4 is linked to myeloid sarcoma.