In addition to VirA/VirG, which is responsible for the expression of vir genes encoded by tumor-inducing plasmid, the chromosome-encoded ChvG/ChvI two-component system is responsible for the expression of acidity-inducible genes, including aopB, encoding an outer membrane protein; pckA, encoding phosphoenolpyruvate carboxykinase; and virG[32]–[36]. This evidence concerns the gene VIPR1 and neoplasm.