In addition, in dendritic cells it seems that miR-155 targets the transcription factor PU.1, thus down-regulating the expression of dendritic cell-specific intercellular adhesion molecule-3 grabbing non-integrin (or DC-SIGN) [44], which is known to bind to the HIV-1 envelope glycoprotein gp120 and to participate in the process of trans-infection [45]. The gene discussed is ERVW-1; the disease is infection.