Only six of the genes induced by overexpressed K15 (lanes 1–2) i.e. pro-melanin concentrating enzyme (PMCH), H2.0 like homeo-box (HLX1), nuclear receptor family 4, subfamily A, group 1 (NR4A1), Regulator of Calcineurin 1/Down syndrome critical region 1 (RCAN1/DSCR1), v-myc myelocytomatosis viral related oncogene (MYCN) and ndrg family member 1 (NDRG1) were found to be induced upon KSHVwt infection and were differentially regulated between KSHVwt- and KSHVΔK15-infected HUVECs in both experiments when a ratio of 2.0 was used as a cut off (figure 1A, lanes 3–4; genes indicated by arrows). This evidence concerns the gene PMCH and infection.