MTOR and infection: Additionally since mTORc1 activation enhances lipid biosynthesis [24] (which is associated with host resistance to Leishmania infection [25]), it is reasonable to speculate that activation of PPAR-γ and SREBP (which link mTOR to fatty acid metabolism) could be an effective strategy for increasing fatty acid production during infection, as this increase in lipid biosynthesis would in turn impair parasite survival.