The mTOR pathway plays a crucial role in neurodevelopmental processes, including cell proliferation, synaptogenesis and growth of dendrites and axons and its perturbation has been implicated in the cognitive deficits of two rare genetic forms of autism spectrum disorders, tuberous sclerosis and fragile X syndrome (Auerbach et al, 2011; Ehninger et al, 2008; Ehninger & Silva, 2011; Swiech et al, 2008). Here, MTOR is linked to tuberous sclerosis.