Most studies on ACPA fine specificity have so far focused on individual antibody responses to epitopes on three citrullinated autoantigens identified in rheumatoid joints: fibrin/fibrinogen [12,13], vimentin [14], and α-enolase [15,16], as well as the skin protein filaggrin, which was used in the early RA-specific tests, before the discovery of the nature of the ACPA response [17,18]. The gene discussed is FLG; the disease is rheumatoid arthritis.