As evidenced by the ataxia exhibited by knockout mice lacking brain-specific (exon 1b-derived) isoforms of the mouse Ank3 gene (Ank3−/− mice) [66], decreased ankyrin G expression affects neuronal performance to a degree that alters functional output, at least in neural circuits specific to motor control and movement. The gene discussed is ANK3; the disease is cerebellar ataxia.