TRANK1 and Behcet disease: Two BD GWAS published in 2011 also reported novel genome-wide significant associations with neurocan (NCAN), an extracellular matrix protein involved in neural adhesion and neurite growth [45], lectin mannose-binding 2-like (LMAN2L) implicated in protein export from the endoplasmic reticulum, the adjacent genes doublecortin-like kinase 3 (DCLK3) and tetratricopeptide repeat and ankyrin repeat containing 1 (TRANK1), the prostaglandin F receptor gene (PTGFR), and a region on chromosome 3p21.2 containing several genes [27,46].