However, many of these studies utilized samples that lacked statistical power to detect small genetic effects such as that of ANK3. Subsequent targeted studies also support CACNA1C association with BD, as well as schizophrenia and major depressive disorder [39-43], suggesting at least partially overlapping genetic etiology across major mental illness, as also proposed by other studies [44]. The gene discussed is CACNA1C; the disease is Behcet disease.