SIRT1 and neoplasm: Advanced tumor stage (P = 0.001), serum AFP level (P = 0.008), serum albumin level (P = 0.029), as well as the expression of SIRT1 (P<0.001), c-Myc (P = 0.001), and p53 (P = 0.001) were all significantly associated with shorter OS according to univariate analysis Advanced tumor stage (P = 0.001), serum AFP level (P = 0.001), serum albumin level (P = 0.017), high histologic grade (P = 0.014) and expression of SIRT1 (P<0.039), c-Myc (P = 0.011), and p53 (P = 0.006) were associated with significantly shorter DFS according to univariate analysis (Figure 5 B).