To determine whether genetic perturbation of dyn1 affects Aβ generation in adult animals in vivo, we next analyzed the levels of Aβ, holoAPP and βCTF in the brains of dyn1 haploinsufficient (dyn1+/−) mice with AD transgenic background expressing human Swedish APP and PS1ΔE9 mutations [25], [26]. The gene discussed is APP; the disease is Alzheimer disease.