CDH1 and Hyperglycemia: Our observations of disrupted E-cadherin interaction between neighbouring ERoSHKHG cells also implicated for the first time the role of hyperglycemia in disrupting gap junctional communication not only in T2D vulnerable cell types such as vascular smooth muscle, endothelial cells, retinal pericytes and astrocytes [72], [73], [74], [75], [76], [77], [78] but also in pancreatic islets.