It is noteworthy that abnormalities in APM gene expression, mainly the downregulation of TAP1, TAP2, LMP7, ERAP1, tapasin, and ERp57 expression, associated with HLA-I in cervical lesions may attribute to deregulation of HLA-I mediated antigen presentation, and the understanding of an immune escape mechanism of tumor cells in cervical carcinogenesis. The gene discussed is TAP2; the disease is neoplasm.