The downregulation of ß2-m,TAP1, TAP2, LMP7, ERAP1, tapasin, and ERp57 protein expression positively associated with HLA-I expression in CIN lesions, whereas ß2-m, TAP1, TAP2, LMP2, LMP7, ERAP1, ERp57, and tapasin expression positively associated with HLA-I in the cancerous lesions. The gene discussed is TAPBP; the disease is cancer.