The results have shown that the development of normal epithelium of uterine cervix to CIN and CSCC was accompanied with altered protein expression of HLA-I, TAP1, TAP2, LMP2, LMP7, ERAP1, tapasin and ERp57 from normal expression to partial loss or total loss of expression in cervical tissue specimens in Immunohistochemical analysis. This evidence concerns the gene TAP2 and cervical squamous intraepithelial neoplasia.