Therefore, considering that aberrant surface expression of HLA-I in cervical cancer associated with high-risk HPV16 infection frequently caused by the absence of APM [17]–[18], one would ask whether epigenetic modifications would modulate the surface expression of HLA-I directly or indirectly by silencing or inactivating of APM component genes and lead to the development of cervical cancer in Uighur women. Here, ANPEP is linked to cervical carcinoma.