In contrast, “hepatic fibrosis/hepatic stellate cell activation” was the most significantly enriched (p<10−12) pathway among the genes exclusively modulated by Klf5 (Table S10), indicative of a general fibrotic response such as that observed in cultured human keratocytes exposed to TGF-β [67]. This evidence concerns the gene TGFB1 and Hepatic fibrosis.