CA2 and glaucoma: Another important change that takes place between PN11 and PN56 corneas is the increased expression of several oxidative stress related genes including ceruloplasmin, an antioxidant enzyme upregulated in different neurodegenerative disorders including glaucoma [38], [39], Arachidonate lipoxygenase-12 and -15, which promote epithelial wound healing and host defense [40], carbonic anhydrase-2, -12, and -13, overexpressed in human glaucoma [41]–[43], and calcium binding proteins S100A8 and A9 (Table 6), suggesting an increase in oxidative stress in the adult compared with the PN11 corneas.