IGFBP3 and neoplasm: (3) Tumor producing complex IGF-II bound to IGF binding protein 2 (IGFBP 2) about 40 kilodaltons in circulation, instead of normal complex IGF-II bound to IGF binding protein 3 (IGFBP3) and acid-labile glycoprotein about 150 to 200 kilodaltons.