PPARG and metabolic dysfunction-associated steatotic liver disease: On the other hand, SKLB102 (a barbituric acid-based derivative PPARγ agonist) was shown to activate lipogenesis and to exacerbate steatosis in mice fed a high-fat/high-calorie diet, although this agonist appears to improve the general outcome of NAFLD/NASH, likely by stimulating insulin sensitivity in both mice or hepatoma cells [30].