Consistent with this study, transcriptional genomic analysis with the liver of PPARβ/δ-deficient mice suggested that PPARβ/δ could have an anti-inflammatory action in the liver [54] and the PPARβ/δ agonist GW501516 was shown to improve hepatic inflammation in mice fed a methionine/choline-deficient diet (a widely used model for NASH) [59]. The gene discussed is PPARD; the disease is metabolic dysfunction-associated steatohepatitis.