Another identified polymorphism, MIA3 rs17465637 A/C, enhances the risk of CVD also in RA, although only in case of concomitant dyslipidemia [28]; MIA3 protein is involved in leukocyte adhesive interactions with vascular endothelium, reduces attachment, and promotes migration of monocytes across the endothelium, thus leading to foam cells and fatty streak appearance with vessel walls [29]. This evidence concerns the gene MIA3 and metabolic syndrome.