In general, adjustment for current BMI and systolic blood pressure did not substantially change the effect estimates (model 2 when compared to model 1); however, adjustment for pre-existing conditions such as history of hypertension, hypercholesterolemia and diabetes (model 3 when compared to model 2) did attenuate the association of binge drinking with PSA levels (Table 4), and prostate cancer risk (Table 5). The gene discussed is KLK3; the disease is Hypertension.