At day 45, all animals experienced a drastic CD4 T cell lymphopenia (Δcounts = −20 and −290 cells/mm3 in animals treated with low dose and −450 and −425 cells/mm3 and in animals treated with high dose) whereas CD8 lymphopenia was only observed in recipients of highest dose of rIL-2 (Δcounts = −335 and −695 cells/mm3) (Figure2). The gene discussed is CD8A; the disease is lymphopenia.