Rare noncoding variants could act as autism susceptibility alleles by altering the level of expression of either NLGN3 or NLGN4X. We sought to determine whether any of the three highly conserved 3’UTR variants of NLGN3 (chrX:70306922) and NLGN4X (chrX:5818136, 5820149–50) could potentially lead to altered neuroligin expression in a luciferase reporter gene assay (Table1). Here, NLGN4X is linked to autism.