Mean (SE) change from baseline in health state index score in responding patients with WT KRAS tumours were positive throughout the study: +0.05 (0.03), +0.07 (0.03), +0.05 (0.03), +0.02 (0.03), +0.05 (0.04) at weeks 8, 16, 24, 32 and safety follow-up visit, respectively. Here, KRAS is linked to neoplasm.