These results are in line with our previous findings in HCCs, in which we compared the expression of CHD1L by IHC between primary HCCs and their paired metastatic tumors, using a tissue microarray containing 50 pairs of primary and metastatic HCCs, and found that overexpression of CHD1L was a key feature in tumor development and metastasis. This evidence concerns the gene CHD1L and metastatic neoplasm.