Periodontal pathogens, such as Porphyromonas gingivalis (P.g.) and Aggregatibacter actinomycetemcomitans (A.a.) are the most important Gram-negative pathogens in the pathogenesis of periodontitis.13 Several studies have investigated antibodies to various periodontal pathogens in relation to CRP14 but evidence is sparse on the association between a direct measure of periodontal pathogens (P.g. and A.a.) and CRP. The gene discussed is CRP; the disease is periodontitis.