TLR4 and nervous system disorder: Dogs with untreated SRMA displayed statistically lower (P <0.01) percentage of TLR4 positive lymphocytes in CSF (SRMA A, median 13%; range 3 to 23.9%) compared to SRMA dogs under therapy (SRMA Th, median 43.8%; range 19.2 to 70.7%;) and dogs with miscellaneous diseases of the nervous system (Mix, median 45.3%; range 33.4 to 56.2%) (see Figure 4F).