TLR4 and nervous system disorder: SRMA dogs showed higher expression (P = 0.0023) of TLR4 positive PB PMNs (SRMA A, median 98.6%; range 98.1 to 99.7%) in comparison to healthy controls (Healthy, median 89.8%; range 82.5 to 93.7%) and to dogs affected with miscellaneous diseases of the nervous system (Mix, median 95.6%; range 94 to 97.5%) (P = 0.0095) (see Figure 2E).