AKT1 and myopathy: The principal goals of this study were to determine if alcohol-related myopathy could be produced experimentally by chronic administration of relatively high levels of ethanol, and assess the degree to which the molecular and biochemical features of alcohol-related myopathy correspond to those associated with alcohol-induced liver and brain degeneration, i.e., insulin/IGF resistance with impaired Akt pathway activation and increased oxidative stress [37].