Studies using the MCF-7 and tamoxifen-resistant (TamR) human breast cancer cell lines showed that ZIP7 mediates a greater increase in intracellular Zn levels in the TamR cell line compared with the non-TamR counterparts, and consequently leads to activation of EGFR, Src, and IGF-1R regulated signaling pathways, promoting growth and invasion [52,162]. The gene discussed is SLC39A7; the disease is breast carcinoma.