These results are rationally linked with the western blotting data of these mitochondrial apoptotic events such as enhancement of Bax expression, simultaneous inhibition of Bcl-2/Bcl-xL, subsequent Bax insert into mitochondria outer membrane, release cytochrome C and cleavage of caspase-3/9 in 11-dehydrosinulariolide-induced apoptosis in melanoma cells. Here, CYCS is linked to melanoma.