BCL2 and melanoma: Our western blotting results found both time- and dose-dependent up-regulation of pro-apoptotic proteins such as cytosolic cytochrome C, cleaved-caspase-3, cleaved-caspase-9, and Bax while pro-caspase-3, pro-caspase-9 and anti-apoptotic factors Bcl-2 as well as Bcl-xL were down-regulated in 11-dehydrosinulariolide-treated melanoma cells (Figure 3C).