Therefore, the current study aimed to determine if there is an ongoing chronic pro-inflammatory process in euthymic bipolar patients with subsyndromal symptoms, characterised by higher concentrations of soluble tumor necrosis factor receptor-1 (sTNF-R1), soluble interleukin-6 receptor (sIL-6R) and soluble interleukin-2 receptor (sIL-2R), all of which are thought to represent reliable markers of inflammatory activity and all of which have been widely investigated in BD. This evidence concerns the gene TNFRSF1A and Behcet disease.