Overexpression of Drg-1 gene in human SW620 metastatic colon cancer cells induces morphological changes that are similar to differentiation-specific changes induced by known differentiation reagents such as tributyrin and a ligand of retinoid X receptor LG268 [30], thus indicating that Drg-1 plays a role in differentiation of tumor cells. The gene discussed is DRG1; the disease is neoplasm.