Individual SNPs associated with HbA1c were located in MTNR1B, SLC2A2, G6PC2, WFS1 and GCKR. All variants were reported to be associated with fasting glucose although rs10010131 in WFS1 was associated with fasting glucose and HbA1c levels only among individuals who developed hyperglycaemia or T2D[18,37] (see Additional file2: Table S2). This evidence concerns the gene WFS1 and Hyperglycemia.